Multiscale Layered Biomechanical Model of the Pacinian Corpuscle

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Electron Microscopy of the Pacinian Corpuscle

The Pacinian corpuscle has a framework of cytoplasmic lamellae arranged concentrically in the outer zone, and bilaterally in the core. Between these is an intermediate growth zone. The inner core shows an unexpected complexity in that its component lamellae are arranged in two symmetrical groups of nested cytoplasmic sheets. Longitudinal tissue spaces form clefts separating the two groups. The ...

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Mechanisms of Mechanotransduction in the Pacinian Corpuscle

Touch perception is important in most living organisms and extremely sensitive detection systems have evolved to meet this need. Pacinian corpuscles (PCs) are primary mechanoreceptors. In the human, they are found in the skin (where they act as touch receptors), in the joints, in muscles and in many organs (where they act as motion sensors). The purpose of the work described in this thesis is t...

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Multiscale Mechanical Model of the Pacinian Corpuscle Shows Depth and Anisotropy Contribute to the Receptor’s Characteristic Response to Indentation

Cutaneous mechanoreceptors transduce different tactile stimuli into neural signals that produce distinct sensations of touch. The Pacinian corpuscle (PC), a cutaneous mechanoreceptor located deep within the dermis of the skin, detects high frequency vibrations that occur within its large receptive field. The PC is comprised of lamellae that surround the nerve fiber at its core. We hypothesized ...

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New Problems in the Functional Activity of the Pacinian Corpuscle

During the last decade, investigations into the mode of function of the Pacinian corpuscle have been focussed almOst exclusively on recording the activity of its nervous components, and some of the more recent histological studies (Quilliam and Sato, 1955; Pease and Quilliam, 1957) have contributed to interpreting the results so obtained. Lately, interesting structural modifications have come t...

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ژورنال

عنوان ژورنال: IEEE Transactions on Haptics

سال: 2015

ISSN: 1939-1412,2329-4051,2334-0134

DOI: 10.1109/toh.2014.2369416